![]() ![]() There are multitudes of studies that actually show a concurrent DECREASE in 4-OHE1, so the mixed results tend to leave me questioning those trying to prove their various products superior. These increases were NOT significant, however, and as you will see and have seen in my various posts, are put out by people with vested interest in other products. ![]() A potential caveat worth further exploration is the increase in production of yet another estrogen exhibited by some studies (4-hydroxyestrone ? this is very potent). I3C modulates these pathways shifting the conversion of estradiol metabolism to favor the 2-hydroxylase pathway and the subsequent 2-OHE1:16alpha-OHE1 ratio is INCREASED, which correlates with a decreased risk of various estrogen-sensitive cancers. This is very important information to someone embarking on post-cycle supplementation.Īlthough there was a failure to achieve statistically significant results in this study, elevated 2-OHE1 urinary levels indicated a decreased risk of prostate cancer, whereas an increased 16alpha-OHE1 urinary level showed an increase of prostate cancer 2-times that of men with the highest levels of 2-OHE1. This simply set precedent, mind you ? although there is a 1% risk for men to develop breast cancer, posting this study is merely the landmark to establish the importance of greater 2-OHE1:16alpha-OHE1 ratios being desired for decreased estrogen-sensitive cancer risk. Measured Items: Diet, other breast cancer risksįindings: Increased level 2-OHE1:16alpha-OHE1 at beginning of study associated with less risk of breast cancer development. Summary of ORDET study of 2000 (always nice fancy acronyms) It was also around that same time that the hypothesis of greater estrogenic metabolism via the 16-alpha-hydroxylase enzyme would yield greater amounts of the more potent 16-alpha-hydroxyestrone (16alpha-OHE1) and a larger number of estrogen-dependent cancers would likely be the result. Several years ago, scientists hypothesized that a preference towards the 2-hydroxylase pathway and the subsequent generation of 2-hydroxyestrone (2-OHE1), results in less toxic metabolites in the circulation, which was subsequently gone on to support a decreased number of breast cancer outcomes if this were the dominant pathway (later, this proved true for prostate cancer as well). Key here, are the enzymes 2-hydroxylase and 16-alpha-hydroxylase. It is metabolized to a number of other chemicals, all with some degree of estrogenic activity. Estradiol is the primary estrogen in circulation (as the example used above in Diversification Model) and one of the most active. The body modifies (metabolizes) estrogens through two mutually exclusive pathways, which lead to compounds with dramatically different biological activities. Guys, you too, are not off the hook as this applies to you as well. ![]() Estrogen receptors are located on the surface of virtually every type of tissue in the human body. That?s right, tell your friends ? ALL ESTROGEN IS NOT CREATED EQUAL. EVIDENCE-BASED EFFICACY: I have written extensively in various posts on my support of this compound versus its DIM metabolite as well as any other compound in the post-cycle realm from the category of ?dietary supplement.? Perhaps the single-most important mechanism of action of I3C is modulating estrogen metabolism. ![]()
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